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Full identifier: http://purl.org/np/RA8FelCvPBxTggV1kWoWeWpAxMHigoTMJwbaz9-O2_B-g#sig

Minted in Nanopublication

RA8FelCvPB comment approve/disapprove edit as derived nanopublication create new with same template

This is a local identifier minted within the nanopublication. http://purl.org/np/RA8FelCvPB...#association This association http://www.w3.org/2000/01/rdf-schema#label has label (this is a literal) "While alcohol induces an increase of dopamine, ondansetron reduces the release of the neurotransmitter by blocking the 5-HT3 receptors. Several studies investigated the effectiveness of ondansetron by dividing alcoholic individuals into two subgroups based on their genotype for the promoter region of the SLC6A4 gene coding for the serotonin transporter (5-HTTLPR L/S polymorphism). The study showed that the patients with the LL genotype treated with ondansetron responded better in terms of alcohol amount and days of abstinence, compared to the other subgroups. Based on these results, researchers have further investigated genotype LL carriers, by analyzing the role of a functional polymorphism of the SLC6A4 gene (rs1042173 [T/G] SNP). The result was that individuals who carry both 5-HTTLPR LL polymorphism and rs1042173 TT polymorphism, treated with ondansetron at the dosage of 0.5 mg/die, present a more effective response to the drug. Unfortunately, the sample of this exploratory study was too small to be validated." .

This is a local identifier minted within the nanopublication. http://purl.org/np/RA8FelCvPB...#association This association http://www.w3.org/1999/02/22-rdf-syntax-ns#subject has drug http://identifiers.org/drugbank/DB00904 DB00904 .

This is a local identifier minted within the nanopublication. http://purl.org/np/RA8FelCvPB...#association This association http://www.w3.org/1999/02/22-rdf-syntax-ns#object has disease http://purl.obolibrary.org/obo/DOID_1574 DOID_1574 .

This is a local identifier minted within the nanopublication. http://purl.org/np/RA8FelCvPB...#association This association https://w3id.org/biolink/vocab/relation has relation http://purl.obolibrary.org/obo/NCIT_C94303 NCIT_C94303 .

This is a local identifier minted within the nanopublication. http://purl.org/np/RA8FelCvPB...#association This association https://w3id.org/biolink/vocab/publications has publications http://www.ncbi.nlm.nih.gov/pubmed/29912214 pubmed/29912214 .

This is a local identifier minted within the nanopublication. http://purl.org/np/RA8FelCvPB...#association This association http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate has predicate https://w3id.org/biolink/vocab/treats treats .

http://identifiers.org/drugbank/DB00904 DB00904 https://w3id.org/biolink/vocab/category is a https://w3id.org/biolink/vocab/Drug Drug .

http://purl.obolibrary.org/obo/DOID_1574 DOID_1574 https://w3id.org/biolink/vocab/category is a https://w3id.org/biolink/vocab/Disease Disease .

http://identifiers.org/drugbank/DB00904 DB00904 http://www.w3.org/1999/02/22-rdf-syntax-ns#type type https://w3id.org/biolink/vocab/Drug Drug .

http://identifiers.org/drugbank/DB00904 DB00904 http://www.w3.org/2000/01/rdf-schema#label label "Ondansetron" .

http://purl.obolibrary.org/obo/DOID_1574 DOID_1574 http://www.w3.org/1999/02/22-rdf-syntax-ns#type type https://w3id.org/biolink/vocab/Disease Disease .

http://purl.obolibrary.org/obo/DOID_1574 DOID_1574 http://www.w3.org/2000/01/rdf-schema#label label "alcohol use disorder" .

This is a local identifier that was minted when the nanopublication was created. http://purl.org/np/RA8FelCvPB...#association association http://www.w3.org/1999/02/22-rdf-syntax-ns#type type https://w3id.org/biolink/vocab...OrPhenotypicFeatureAssociation ChemicalToDiseaseOrPhenotypicFeatureAssociation .

This is a local identifier that was minted when the nanopublication was created. http://purl.org/np/RA8FelCvPB...#association association https://w3id.org/biolink/vocab/aggregator_knowledge_source aggregator_knowledge_source https://w3id.org/biolink/infores/knowledge-collaboratory knowledge-collaboratory .

This is a local identifier that was minted when the nanopublication was created. http://purl.org/np/RA8FelCvPB...#association association https://w3id.org/biolink/vocab/category category https://w3id.org/biolink/vocab...OrPhenotypicFeatureAssociation ChemicalToDiseaseOrPhenotypicFeatureAssociation .

This is a local identifier that was minted when the nanopublication was created. http://purl.org/np/RA8FelCvPB...#association association https://w3id.org/biolink/vocab/has_population_context has_population_context This is a local identifier that was minted when the nanopublication was created. http://purl.org/np/RA8FelCvPB...#context context .

This is a local identifier that was minted when the nanopublication was created. http://purl.org/np/RA8FelCvPB...#context context http://www.w3.org/1999/02/22-rdf-syntax-ns#type type https://w3id.org/biolink/vocab/Cohort Cohort .

This is a local identifier that was minted when the nanopublication was created. http://purl.org/np/RA8FelCvPB...#context context http://www.w3.org/2000/01/rdf-schema#label label "adults" .

This is a local identifier that was minted when the nanopublication was created. http://purl.org/np/RA8FelCvPB...#context context https://w3id.org/biolink/vocab/category category https://w3id.org/biolink/vocab/Cohort Cohort .

This is the identifier for the assertion of this nanopublication. http://purl.org/np/RA8FelCvPB...#assertion The assertion above http://www.w3.org/ns/prov#wasAttributedTo wasAttributedTo https://orcid.org/0000-0002-7641-6446 0000-0002-7641-6446 .

This is the identifier for this whole nanopublication. http://purl.org/np/RA8FelCvPB... This nanopublication links to the assertion template that was used to create this nanopublication https://w3id.org/np/o/ntemplate/wasCreatedFromTemplate was created from the assertion template http://purl.org/np/RAhNHZw6Ur... RAhNHZw6Ur .

This is a local identifier minted within the nanopublication. http://purl.org/np/RA8FelCvPB...#sig sig http://purl.org/nanopub/x/hasSignatureTarget has as target This is the identifier for this whole nanopublication. http://purl.org/np/RA8FelCvPB... this nanopublication .

This is a local identifier minted within the nanopublication. http://purl.org/np/RA8FelCvPB...#sig sig http://purl.org/nanopub/x/hasAlgorithm has the algorithm (this is a literal) "RSA" .

This is a local identifier minted within the nanopublication. http://purl.org/np/RA8FelCvPB...#sig sig http://purl.org/nanopub/x/hasPublicKey has the public key (this is a literal) "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCR9fz0fKCdWOWC+pxhkQhEM/ppbdIYe5TLSdj+lJzSlv9mYBaPgrzVezSwwbmhlHBPDZa4/vHycU315BdmUGq+pXllp9+rWFfrb+kBJwhZjpG6BeyyXBsRFz4jmQVxl/ZYHilQTh/XalYzKkEAyTiEMPee4Kz61PaWOKH24CsnOQIDAQAB" .

This is a local identifier minted within the nanopublication. http://purl.org/np/RA8FelCvPB...#sig sig http://purl.org/nanopub/x/hasSignature has the signature (this is a literal) "Amf2NBNpvSMgD1GnrMQcNJ669LPBQoTJYYwl3ipoapQkPeN8/oq1blWCDCMjt5abhgU+qt3ZKJjPKiZv7ePNUwa5z2K9Qf52NWKRGq3ms8O9ItnTUFqeK8EDwfQGVS5cw2MFhU6HqMUHiBl1uDY83uSaNB4tYCQksQmasx04cjQ=" .

https://w3id.org/biolink/vocab/ vocab http://purl.org/pav/version version (this is a literal) "2.3.0" .

This is the identifier for this whole nanopublication. http://purl.org/np/RA8FelCvPB... this nanopublication http://www.w3.org/ns/prov#generatedAtTime generatedAtTime (this is a literal) "2022-09-16T11:54:31.167009" .

This is the identifier for this whole nanopublication. http://purl.org/np/RA8FelCvPB... this nanopublication http://www.w3.org/ns/prov#wasAttributedTo wasAttributedTo https://orcid.org/0000-0002-1501-1082 Vincent Emonet .

Vincent Emonet, 16 Sep 2022, 11:54:31 UTC

References

Nanopublication	Part	Subject	Predicate	Object	Published By	Published On
http://purl.org/np/RA8FelCvPB... RA8FelCvPB	links a nanopublication to its pubinfo http://www.nanopub.org/nschema#hasPublicationInfo pubinfo	sig	http://purl.org/nanopub/x/hasAlgorithm hasAlgorithm	RSA	Vincent Emonet	2022-09-16T11:54:31.167Z
http://purl.org/np/RA8FelCvPB... RA8FelCvPB	links a nanopublication to its pubinfo http://www.nanopub.org/nschema#hasPublicationInfo pubinfo	sig	http://purl.org/nanopub/x/hasPublicKey hasPublicKey	MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCR9fz0fKCdWOWC+pxhkQhEM/ppbdIYe5TLSdj+lJzSlv9mYBaPgrzVezSwwbmhlHBPDZa4/vHycU315BdmUGq+pXllp9+rWFfrb+kBJwhZjpG6BeyyXBsRFz4jmQVxl/ZYHilQTh/XalYzKkEAyTiEMPee4Kz61PaWOKH24CsnOQIDAQAB	Vincent Emonet	2022-09-16T11:54:31.167Z
http://purl.org/np/RA8FelCvPB... RA8FelCvPB	links a nanopublication to its pubinfo http://www.nanopub.org/nschema#hasPublicationInfo pubinfo	sig	http://purl.org/nanopub/x/hasSignature hasSignature	Amf2NBNpvSMgD1GnrMQcNJ669LPBQoTJYYwl3ipoapQkPeN8/oq1blWCDCMjt5abhgU+qt3ZKJjPKiZv7ePNUwa5z2K9Qf52NWKRGq3ms8O9ItnTUFqeK8EDwfQGVS5cw2MFhU6HqMUHiBl1uDY83uSaNB4tYCQksQmasx04cjQ=	Vincent Emonet	2022-09-16T11:54:31.167Z
http://purl.org/np/RA8FelCvPB... RA8FelCvPB	links a nanopublication to its pubinfo http://www.nanopub.org/nschema#hasPublicationInfo pubinfo	sig	http://purl.org/nanopub/x/hasSignatureTarget hasSignatureTarget	http://purl.org/np/RA8FelCvPB... RA8FelCvPB	Vincent Emonet	2022-09-16T11:54:31.167Z

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