Nanopublication

A regulatory element within the first intron of FTO affects IRX3 and IRX5 expression during early adipogenesis DataScience SuperPatternInstance

this super-pattern instance https://w3id.org/kpxl/ios/ds/np/RApCUXhnav...#spi SPI: links a thing (left) to a class it belongs (right) http://www.w3.org/1999/02/22-rdf-syntax-ns#type This is a a statement that conforms to the super-pattern https://w3id.org/linkflows/superpattern/terms/SuperPatternInstance super-pattern instance .

this super-pattern instance https://w3id.org/kpxl/ios/ds/np/RApCUXhnav...#spi SPI: links a formal identifier (left) to a human-readable name (right) http://www.w3.org/2000/01/rdf-schema#label Informally, it can be shown as (this is a literal) "A regulatory element within the first intron of FTO affects IRX3 and IRX5 expression during early adipogenesis" .

this super-pattern instance https://w3id.org/kpxl/ios/ds/np/RApCUXhnav...#spi SPI: specifies the context class (right) for the given super-pattern instance (left) https://w3id.org/linkflows/superpattern/terms/hasContextClass In the context of all things of type http://purl.org/np/RAtsHwzNs3...#early-human-adipogenesis early-human-adipogenesis .

this super-pattern instance https://w3id.org/kpxl/ios/ds/np/RApCUXhnav...#spi SPI: specifies the subject class (right) for the given super-pattern instance (left) https://w3id.org/linkflows/superpattern/terms/hasSubjectClass ... things of type http://purl.org/np/RAxLYvJ1JrR...within-the-first-intron-of-FTO regulatory-element-within-the-first-intron-of-FTO .

this super-pattern instance https://w3id.org/kpxl/ios/ds/np/RApCUXhnav...#spi SPI: specifies the qualifier (right) for the given super-pattern statement (left) https://w3id.org/linkflows/superpattern/terms/hasQualifier ... (qualifier) https://w3id.org/linkflows/superpattern/terms/generallyQualifier generally .

this super-pattern instance https://w3id.org/kpxl/ios/ds/np/RApCUXhnav...#spi SPI: specifies the relation type (right) for the given super-pattern statement (left) https://w3id.org/linkflows/superpattern/terms/hasRelation ... have a relation of type https://w3id.org/linkflows/superpattern/terms/affects affects .

this super-pattern instance https://w3id.org/kpxl/ios/ds/np/RApCUXhnav...#spi SPI: specifies the object class (right) for the given super-pattern instance (left) https://w3id.org/linkflows/superpattern/terms/hasObjectClass ... to things of type http://purl.org/np/RAwkXiTv7q...#expression-of-genes-IRX3-and-IRX5 expression-of-genes-IRX3-and-IRX5 .

This is the identifier for the assertion of this nanopublication. https://w3id.org/kpxl/ios/ds/np/RApCUXhnav...#assertion The assertion above http://www.w3.org/ns/prov#wasGeneratedBy was generated by This is a local identifier minted within the nanopublication. https://w3id.org/kpxl/ios/ds/np/RApCUXhnav...#activity Formalization-Activity .

This is a local identifier minted within the nanopublication. https://w3id.org/kpxl/ios/ds/np/RApCUXhnav...#activity Formalization-Activity http://www.w3.org/1999/02/22-rdf-syntax-ns#type is a https://w3id.org/linkflows/superpattern/terms/FormalizationActivity formalization activity .

This is a local identifier minted within the nanopublication. https://w3id.org/kpxl/ios/ds/np/RApCUXhnav...#activity Formalization-Activity http://www.w3.org/ns/prov#used used https://doi.org/10.1056/NEJMoa1502214 doi:10.1056/NEJMoa1502214 .

This is a local identifier minted within the nanopublication. https://w3id.org/kpxl/ios/ds/np/RApCUXhnav...#activity Formalization-Activity http://www.w3.org/ns/prov#wasAssociatedWith was associated with https://orcid.org/0000-0003-2432-4125 Amelia Joslin .

This is a local identifier minted within the nanopublication. https://w3id.org/kpxl/ios/ds/np/RApCUXhnav...#activity Formalization-Activity http://www.w3.org/ns/prov#used used This is a local identifier minted within the nanopublication. https://w3id.org/kpxl/ios/ds/np/RApCUXhnav...#quote source quote .

This is a local identifier minted within the nanopublication. https://w3id.org/kpxl/ios/ds/np/RApCUXhnav...#quote Source quote http://www.w3.org/ns/prov#value has the value (this is a literal) "The rs1421085 T-to-C single-nucleotide variant disrupts a conserved motif for the ARID5B repressor, which leads to derepression of a potent preadipocyte enhancer and a doubling of IRX3 and IRX5 expression during early adipocyte differentiation." .

This is a local identifier minted within the nanopublication. https://w3id.org/kpxl/ios/ds/np/RApCUXhnav...#quote Source quote http://www.w3.org/ns/prov#wasQuotedFrom was quoted from https://doi.org/10.1056/NEJMoa1502214 doi:10.1056/NEJMoa1502214 .

This is the identifier for this whole nanopublication. https://w3id.org/kpxl/ios/ds/np/RApCUXhnav... This nanopublication http://purl.org/dc/terms/creator is created by https://orcid.org/0000-0002-1267-0234 me (Tobias Kuhn) .

https://orcid.org/0000-0002-1267-0234 Tobias Kuhn http://xmlns.com/foaf/0.1/name has the name (this is a literal) "Tobias Kuhn" .

https://orcid.org/0000-0003-2432-4125 Amelia Joslin http://xmlns.com/foaf/0.1/name has the name (this is a literal) "Amelia Joslin" .

This is the identifier for this whole nanopublication. https://w3id.org/kpxl/ios/ds/np/RApCUXhnav... This nanopublication http://purl.org/dc/terms/license is published under the license https://creativecommons.org/licenses/by/4.0/ Attribution 4.0 International (CC BY 4.0) .

This is the identifier for this whole nanopublication. https://w3id.org/kpxl/ios/ds/np/RApCUXhnav... This nanopublication http://purl.org/dc/terms/isPartOf is a part of https://doi.org/10.3233/DS-210038 doi:10.3233/DS-210038 .

This is the identifier for this whole nanopublication. https://w3id.org/kpxl/ios/ds/np/RApCUXhnav... This nanopublication http://www.w3.org/ns/prov#wasDerivedFrom was derived from http://purl.org/np/RAxBBJ2Wko... RAxBBJ2Wko .

This is the identifier for this whole nanopublication. https://w3id.org/kpxl/ios/ds/np/RApCUXhnav... This nanopublication https://w3id.org/linkflows/reviews/isUpdateOf is an update of http://purl.org/np/RAxxJWyH8O... RAxxJWyH8O .

This is the identifier for this whole nanopublication. https://w3id.org/kpxl/ios/ds/np/RApCUXhnav... This nanopublication http://purl.org/nanopub/x/hasNanopubType has the type https://w3id.org/kpxl/ios/ds/terms/DataScienceNanopub DataScienceNanopub .

This is the identifier for this whole nanopublication. https://w3id.org/kpxl/ios/ds/np/RApCUXhnav... This nanopublication http://purl.org/ontology/bibo/authorList has This is a local identifier minted within the nanopublication. https://w3id.org/kpxl/ios/ds/np/RApCUXhnav...#author-list this author list .

This is a local identifier minted within the nanopublication. https://w3id.org/kpxl/ios/ds/np/RApCUXhnav...#author-list This author list This relation links a sequence/list to its element at position 1. http://www.w3.org/1999/02/22-rdf-syntax-ns#_1 has at position 1 https://orcid.org/0000-0003-2432-4125 Amelia Joslin .

This is the identifier for this whole nanopublication. https://w3id.org/kpxl/ios/ds/np/RApCUXhnav... This nanopublication date and time when the nanopublication was created http://purl.org/dc/terms/created was created on (this is a literal) "2024-07-12T07:23:33.284Z" .

This is the identifier for this whole nanopublication. https://w3id.org/kpxl/ios/ds/np/RApCUXhnav... This nanopublication links to the assertion template that was used to create this nanopublication https://w3id.org/np/o/ntemplate/wasCreatedFromTemplate was created from the assertion template http://purl.org/np/RAy3tITXPl... RAy3tITXPl .

This is the identifier for this whole nanopublication. https://w3id.org/kpxl/ios/ds/np/RApCUXhnav... This nanopublication links to the provenance template that was used to create this nanopublication https://w3id.org/np/o/ntemplate/wasCreatedFromProvenanceTemplate was created from the provenance template http://purl.org/np/RAB_oy10D3... RAB_oy10D3 .

This is the identifier for this whole nanopublication. https://w3id.org/kpxl/ios/ds/np/RApCUXhnav... This nanopublication links to the publication info template that was used to create this nanopublication https://w3id.org/np/o/ntemplate/wasCreatedFromPubinfoTemplate was created from the publication info template http://purl.org/np/RAA2MfqdBC... RAA2MfqdBC .

This is the identifier for this whole nanopublication. https://w3id.org/kpxl/ios/ds/np/RApCUXhnav... This nanopublication the nanopublication consists of an introduction of the given resource http://purl.org/nanopub/x/introduces introduces This is a local identifier minted within the nanopublication. https://w3id.org/kpxl/ios/ds/np/RApCUXhnav...#spi spi .

This is a local identifier minted within the nanopublication. https://w3id.org/kpxl/ios/ds/np/RApCUXhnav...#sig sig http://purl.org/nanopub/x/hasSignatureTarget has as target This is the identifier for this whole nanopublication. https://w3id.org/kpxl/ios/ds/np/RApCUXhnav... this nanopublication .

This is a local identifier minted within the nanopublication. https://w3id.org/kpxl/ios/ds/np/RApCUXhnav...#sig sig http://purl.org/nanopub/x/hasAlgorithm has the algorithm (this is a literal) "RSA" .

This is a local identifier minted within the nanopublication. https://w3id.org/kpxl/ios/ds/np/RApCUXhnav...#sig sig http://purl.org/nanopub/x/hasPublicKey has the public key (this is a literal) "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQD4Wj537OijfOWVtsHMznuXKISqBhtGDQZfdO6pbb4hg9EHMcUFGTLbWaPrP783PHv8HMAAPjvEkHLaOHMIknqhaIa5236lfBO3r+ljVdYBElBcLvROmwG+ZGtmPNZf7lMhI15xf5TfoaSa84AFRd5J2EXekK6PhaFQhRm1IpSYtwIDAQAB" .

This is a local identifier minted within the nanopublication. https://w3id.org/kpxl/ios/ds/np/RApCUXhnav...#sig sig http://purl.org/nanopub/x/hasSignature has the signature (this is a literal) "ir8i/lid0qJdL3r1A0r88pq0/XDOVb9XdRxAvsb95TYju6NXBF6OBfLcsz/nEgJ3nGQagKQAFT24d3flmc1zAb+BDO3Ewoq1j/ngmn7nPsYb57D0OFFAKpSGdDJdD8DEWOiejuKGbN+VuW5c3zwRU5MS3VJQpEGRFZym2YuMFbs=" .

This is a local identifier minted within the nanopublication. https://w3id.org/kpxl/ios/ds/np/RApCUXhnav...#sig sig http://purl.org/nanopub/x/signedBy is signed by https://orcid.org/0000-0002-1267-0234 Tobias Kuhn .

This is the identifier for this whole nanopublication. https://w3id.org/kpxl/ios/ds/np/RApCUXhnav... This nanopublication http://purl.org/nanopub/x/wasCreatedAt was created at https://nanodash.knowledgepixels.com/ nanodash.knowledgepixels.com .

Amelia Joslin (author), Tobias Kuhn (creator), 12 Jul 2024, 07:23:33 UTC

Type Description This is the description of the type this nanopublication belongs to.

This nanopublication makes a statement that in the context of a thing of a certain type (e.g. a mouse), another thing of a certain type (e.g. a gene) tends to have a relation (such as causing) to another thing of a certain type (e.g. a disease) in the same context.

Note that the context is not a reference to a general topic or field. It denotes the class for the context in which the relations happen. If each relation is happening in a human, for example, such as a certain condition leading to a certain symptom, then the context class should be 'human'.

The technical background of the super-pattern can be found in this publication.

Candidate

This nanopublication is a candidate for inclusion in the journal, but is not peer-reviewed and has at this point no formal link to the journal.

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